𝗖𝗜𝗥𝗖𝗨𝗟𝗔𝗥 𝗥𝗡𝗔 — 𝗧𝗛𝗘 𝗥𝗡𝗔 𝗧𝗛𝗔𝗧 𝗥𝗘𝗙𝗨𝗦𝗘𝗦 𝗧𝗢 𝗘𝗡𝗗 𝗪𝗵𝗮𝘁 𝗮𝗿𝗲 𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝗿 𝗥𝗡𝗔𝘀? Circular RNAs (circRNAs) are covalently closed RNA molecules formed by back-splicing, where a downstream 5′ splice donor joins an upstream 3′ splice acceptor, creating a continuous loop without 5′ or 3′ ends. 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗙𝗲𝗮𝘁𝘂𝗿𝗲 Because circRNAs lack free ends, they are resistant to exonucleases such as RNase R, making them significantly more stable than linear m
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𝗖𝗜𝗥𝗖𝗨𝗟𝗔𝗥 𝗥𝗡𝗔 — 𝗧𝗛𝗘 𝗥𝗡𝗔 𝗧𝗛𝗔𝗧 𝗥𝗘𝗙𝗨𝗦𝗘𝗦 𝗧𝗢 𝗘𝗡𝗗 𝗪𝗵𝗮𝘁 𝗮𝗿𝗲 𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝗿 𝗥𝗡𝗔𝘀? Circular RNAs (circRNAs) are covalently closed RNA molecu…
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